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Literally, "Picture unrelated" Said whenever a picture has nothing to do with the regarding topic. Mostly used in imageboards.
Today was my first day at work. Everything's getting better than before!

p/u
p/u by anonhacks November 2, 2010
Related Words
An excalamtion denoting the presence a vile or unpleasant odor.
"P.U.," either use deodorant or keep your arms down!
p.u. by Anonymous August 24, 2003
Pronounced "Pee Yew" and also spelled "P U" or spelled out "Pfew!", "Phew!," or "Pee-yew!" this aging American interjection, often accompanied with a pinched nose or similar disgusted gesture, indicates the existence of a foul or overpowering odor. Its use seems to have peaked in the mid-Twentieth Century as a semi-euphemism for olfactory revulsion, but is still occasionally used today.
Betty: Archie, what happened to you? P U! (Waves hand in front of face)

Archie (red-faced): I fell in a pickle barrel at the grocery store.

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Sweet Dee Reynolds (in TV show "It's Always Sunny in Philadelphia," ca. 2010): Moms stink! P.U.!!

(episode "Frank Reynolds' Little Beauties," September 29, 2011)
P.U. by al-in-chgo May 24, 2018
Help Help PU alert alert
P.U. by Stina February 17, 2004
"Man, girls, look at those muscles on WC!"
"I knooooww, does he go to P.U. or what?"
P.U. by WC September 15, 2004
Sarah: you saw the cute guy from school?
Jessie: yeah, we are friends... want me to p.u.o?
Sarah: YESSS!
P.U.O by misslea.\ October 24, 2020