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Richard Pryor's most famous character. Occurs frequently in his stand up routines. A philosophical drunkard from Toledo Mississippi. Can be used as an adjective, verb, or pronoun (often pejoratively) to describe someone who often fashions surrealist drunk ramblings.
Popular example:
She's got the wings and the teeth of an African bat,
Her middle name is Mudbone and on top of all that,
Ya mama's got a glass eye with a fish in it.

--Ya Mama, The Pharcyde

Adjective:
(To a Mudbone Motherfucker) You such a Mudbone Motherfucker!

Verb:
Yo you see Jamal at the bar last night? He was Mudbonin' some bitch for like 40 minutes.
Mudbone by aljezzera December 9, 2009
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A porno actor for pornpros site freaks of cock. Wears a large obviously fake penis over his own average one. His moneyshot scenes are ludicrous with about a gallon of simulated baby gravy.
Greg: Dude check out Mudbone in this clip his balls totally fall out of his fakie!

Rich: Why are you watching that crap?
Mudbone by Guylanda December 31, 2008
Something of large proportions, often used as an adjective, although it can also be used in simile and metaphor form. His cumshots are also much like milk, so there may also be references to that.
Named after pornstar O.G. Mudbone, famous for his 14" penis.
"How are you?"

"Tired as a bitty after taking a mudbone."
Mudbone by Bill Roswell January 5, 2009
Refers to the penis after anal sex, or to anal sex in general.
I totally mudboned her last night.
mudbone by M. Murphy October 13, 2005
The act of getting screwed over egregiously, especially in Madden 20
Dude you got mudboned!
Mudbone by Skadoo Action January 11, 2020
A voluptuous man who you wanna softly rub
Hey man look at that mudbone over there might have a sword fight tonight
Mudbone by Hi234502825193 August 5, 2019

Mudbone Hustler 

A mudbone hustler is someone who doesn't have much cash, but always seems to get by in style. This is a person who uses their wits to avoid being a "starving artist", but they aren't exactly getting rich either.

At any Phish show you'll see a pack of mudbones selling hemp necklaces trying to get enough for a ticket and some food.

The term originated from the Richard Pryor character Mudbone, who was a shoe shiner who'd been around the block a time or two.
That fool just made a bunch of 10 cent copies of his drawings and is selling them outside the show for a buck each. He lives in his car but he's at all the best shows with a drink in his hand, what a mudbone hustler!
Mudbone Hustler by DJ Easybake September 25, 2010