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1 - Slang term for the drug methaqualude or simple quaaludes, a barbituate like Central Nervous depressant drug which causes clumsiness and fatigue, often used to treat insomnia and anxiety.

2 - "TO BE ON LUDES": Idiotical, Dull Minded, Dim-Witted, Stupid, Lacking intelligence, Feeble Minded.
1 - My doc recommended i take ludes for my insomnia, there illegal but TS.

2 - WTF?? Are you on ludes mate? dont you know what im getting at? you cant even follow the simplist of instructions cant you?
ludes by Brother Number One August 22, 2005
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its a tranq from long ago
"ludes man FUCKING ludes!!! call up the ludes dude dude and get some fucking ludes"
ludes by Tarryn November 27, 2004
Vitamin Q, Quakers, Quas, Q's, Disco Biscuits, Mandies,
Lemmons, Wallbangers, Quacks. Real name Methaqualone. A drug synthesized back in 1951 in India by two men named Indra Kishore and Hussain Zaheer. Was commonly used at clubs back in the 60's and 70's at discos (hence the name "Disco Biscuits") to make you feel better while you danced and partied. There were also special bars where they would serve non alcoholic beverages to cater to the people who used it. Now in decline due to it being declared a Schedule 1 substance.
Ludes used to be the one and only college past time.
Ludes by Matt the stud June 19, 2010
Vitamin Q, Quakers, Quas, Q's, Disco Biscuits, Mandies,
Lemmons, Wallbangers, Quacks. Real name Methaqualone. A drug synthesized back in 1951 in India by two men named Indra Kishore and Hussain Zaheer. Was commonly used at clubs back in the 60's and 70's at discos (hence the name "Disco Biscuits") to make you feel better while you danced and partied. There were also special bars where they would serve non alcoholic beverages to cater to the people who used it. Now in decline due to it being declared a Schedule 1 substance.
Ludes used to be the one and only college past time.
Ludes by jkiller212 June 11, 2010
Light Nudes, social media tolerated level of nudes. Naughty but won’t get you fired.
He asked for nudes but I’m saving the good ones for later, so I sent him a few Ludes instead.
Ludes by Naughty Mouth January 20, 2021
n. 1. Quaaludes
2. what you take when you don't have shit else
What kind of shit you got? I ain't got shit, let's get some fucking ludes or some shit
ludes by jimmy ivory April 2, 2004
that mistake made me so pissed off i had to take some ludes to cool down.