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Regardless of what all these other bullshit entries say, otown is most widely known as the nickname of Orlando, Florida. Not fucking ottowa or ohio or whatever.
Homie:Yo dawg lets go to orlando, also known as O-town.
Dawg:Word.
O-Town by Dick F. April 9, 2009
Shortened term for Orlando, Florida.
We be too crunk down in O-Town.
O-Town by Sessa November 2, 2005
Nickname for many cities beginning with the letter 'O'. Anyone living near such a city believes their city is the only true O-Town.
Ottawa, Canada is known as O-Town.
O-Town by Mister Marbles September 25, 2010
O-town is the name of the fictional city in which the animated series "Rocko's Modern Life" took place.

(thats old-skool nickelodeon for all you little kids :-P)
Supposedly located on the border between Michigan and Canada.

Rocko and Heffer live in O-town.
O-Town by kirE May 6, 2006
Suck-ass boyband who only has fans because they are "sooo cute".
O-Town can't sing for shit, as with most boybands. Equally retarded are N*Sync, Backstreet boys, Linkin Park, etc.
O-Town by Anonymous August 13, 2003
An orgasm so good it feels like a different plane of existence.
Girl 1: Hey, how was your hook-up last night?
Girl 2: Oh my god, amazing. He took me to fucking O-town last night.
O-town by JonieRabbit April 27, 2016