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Holmes disease

When you have an above average penis size.

In reference to John Holmes 🤘🏻
Wife:That's my husband TYLER LEE!

Random ex- metal bandmate: FUCK YEAH! MY BOY, HE HAS HOLMES DISEASE! His stage excitement could be seen for miles!

Brooklyn Taylor Coca-Cola Pepsi Sherlock Loki Thomas Holmes Nanette de Douglestrauff Anderson Cockroach 

Brooklyn’s full name. Brooklyn is a kind and loyal person, and you would be lucky to be a friend of this Russian spy. But here’s a tip; steal her sunglasses. A way to bond for life.
Brooklyn Taylor Coca-Cola Pepsi Sherlock loki Thomas Holmes Nanette de Douglestrauff Anderson Cockroach is a Russian spy’s full name.

Well no dip Sherlock Holmes 

Something you tell someone who states the obvious. More school friendly.

Similar:
No shit! (Less school friendly).
Example:

Guy 1: Hey! It's freaking cold as heck out here!
Guy 2: Well no dip Sherlock Holmes!

Doing a holmes 

This is when, instead of going out with all of your friends. you just stay in and be lame
You coming out tonight?
Nah
Dude. don't do a holmes on me
no way man, I'm doing a holmes
Doing a holmes by thornville boyzzz November 13, 2011

Drew Holmes 

gypsy cock sucking nigger boy, fucks cats and goats, like to get felched by his grandpa and he like to get pounded hard in the ass by a horse with a 12 foot cock.
Stranger 1: Hey enrique did you see that nigger faggot getting fucked by a horse over there?
Stranger 2: Yeah he must be a Drew Holmes
Drew Holmes by derponymos January 19, 2012

Damien Holmes

term used to describe a man that attacks the world with a sword of optimism. A man who looks at failure with a confused face, because he's never encountered it. A man who questions nothing, because he knows everything. Synonyms include: Perfection, Flawless, Swaggerific
Girl: I dont like blind dates

Woman: But this guy is like Damien Holmes

Girl: Disregard my last statement. I'm in
Damien Holmes by Billy Hellyeah November 3, 2011