"Hey, look at that drunklet dancing in the corner, she would probably be an easy fuck"
"You are right man, she does not even know where she is! Let's go for it!"
That drunk uncle everybody has who always gets hammered at family events. Usually this individual will puke, cause a fight or both and is estimated to have a short life expectancy.
A drunk uncle. The classic situation when one of you parent's brothers drinks far too much at some sort of social event, thus resulting in them performing an embarrassing act. Hence they are a Drunkle.