Enflamed and enraged hemorrhoids that are itching worse than a case of chicken pox. Rendering the person in a miserable, squirming state longing for relief from a medicated pad or salve.
Carl's job as a trucker often rendered him on the long hauls with a case of itchy barnacles. He frequently had to make stops along the way for a little rectal ointment to smooth the fire.
Said in response to a statement that is believed to be false. The previous example where the statement is "Do you believe in God?" and the response is "Itchy beard" is wrong simply because a question cannot be false.