Taken from last name of "supposed" pop sensation Hillary Duff. ...When the loss of one's innocence is suddenly cool and popular. ...Drastically becoming something your not overnight.
Verb (past tense) : The act of being penetrated in one's anus by sac encased male genitalia. Often leads to a tearing of the inner anus, causing the need for stitches. Causes sticky situations when the Duffer has to tell the Duffee's parents.
"Hey man, did you hear the news? last night caitie got duffed!" or "Dammit, my science teacher duffed me on that lab report."
"Are you really gonna duff me like that?"
A gay ass bitch who's very ugly but good at math so all the Mexican kids at school are friends with him just so he will do their homework for them. Also he's very good at talking shit about people's mom.