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Acronym for You Only Live Once.

Now get off your computer and go outside.
George came to the party with the word Y.O.L.O. on his shirt and got things started.
Y.O.L.O. by THC420 December 27, 2009
Related Words

Y.O.D.A. S.A.P 

You Only Do Anal
Suck A Penis

A catchy and effective phrase
Great for a comeback.

Can be used in any context you like
Bob: Hey Builder you suck at maths!
Builder: go Suck a penis

Bob: Hey Builder you're gay
Builder: Y.O.D.A. S.A.P !!!
Y.O.D.A. S.A.P by DBLXY September 18, 2012
Me: "I'm going to get up this morning and take advantage of today! Y.O.L.O!
Y.O.L.O by somerandomdude69 July 13, 2012
Y-You'll
O-Only
D-Die
A-Anyway

A mock of the famous saying, Y.O.L.O. It was made by the creativity of some people. Y.O.D.A actually makes more sense than Y.O.L.O.
A guy makes a tragic decision. He than says YOLO. He might end up in a big mess. So Y.O.D.A