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onee-sama 

A Japanese term made of these parts:
1. The 'o-' prefix, indicating a respectful tone.
2. 'nee', meaning 'sister'.
3. The '-sama' suffix, an honorific denoting extreme respect as might be used when addressing noble figures or gods.

Onee-sama is an unusual, overly formal way of referring to one's sister. For most everyday purposes, the neutrally formal 'onee-san' or familiar 'onee-chan' would suffice: only those raised in highly formal settings would even contemplate using 'onee-sama' in a non-sarcastic way (as one might say in English 'oh of course your highness').

'Onee-sama' is a term mostly popularised by manga and anime, specifically shoujo-ai (love between young girls) series set in high-class boarding schools (see Strawberry Panic for a textbook example). Because of this association, 'onee-sama' is inextricably tied to the more elegant side of the shoujo-ai genre: a young girl using the term to address an older, unrelated girl could be hinting at a deeper relationship between the two of them. Or they could just be messing with you.
IRL (sort of): "Onee-sama, I hope you aren't labouring under the misapprehension that your seniority over me justifies you putting on airs."
Shoujo-ai fantasy: "Onee-sama, would you please become my soeur?"
onee-sama by Kazzius November 22, 2013
Related Words
Samael samae samaela Samaemo Samaera Samaesha samaey sama Samaira Samah

Nee-sama 

Means sister in Japanese often people who watch the popular Anime Re:Zero will use it.
Rem: Nee-sama Nee-sama, could our guest be a troubled man, deriving pleasure from torture?
Ram: Rem, Rem our guest appears to be a pervert who's turned on by our insults.
Nee-sama by Vesy November 16, 2017
Samadi is sweet and funny and cute and means peace and tranquility
samadi by Cite July 4, 2015
sama is a friend thats always there for you and never fails to make u feel better . shes a great listener and supporter , once u get close to her she becomes a very important person in your life , she is insanely pretty and wholesome
sama was the only one there for me through hard times
sama by jayjayyyyyyy November 15, 2019

kaichou wa maid sama 

kaichou wa maid sama or short kwms is japanese manga made by hiro fujiwara. manga has 86 chapters in 15 volumes and anime with 24 episodes.
person no.1:did you watch that awesome anime?
person no.2:do you mean kaichou wa maid sama? yeah it was awesome
person no.1:i know that you would like it
kaichou wa maid sama by kaja-chan August 31, 2016
The most genuine person you will ever meet. easy to get along with. and is true. has a pure heart. and is always there to give a helping hand.
I wish my man was a samad.
Samad by Dr.ritchy July 18, 2009