Irritable Barden Syndrome 

A disease in the category of mental retardation. The center of a mammal's brain is taken over by Dringi. The disease causes the host to always be irritable, as if there is a huge wooden thorn in their left foot. Typical side effects are a whooping cough and Mononucleosis for 17 years. There is only one creature known to have this unfortunate disease.

I am not feeling well. I think I have Irritable Barden Syndrome.

Irritable Barden Syndrome by 1011B January 29, 2014

Irritable Brain Syndrome 

This is the name for something that is putting alot of stress on your mind and causing you annoyance.

This job is giving me irritable brain syndrome!

She/He makes me feel like I have irritable brain syndrome!

Irritable Brain Syndrome by The Spooky Twigg October 29, 2004

Irritable Project Syndrome 

Irritable Project Syndrome (IPS)

Occurs when most members of a project team get extremely crabby and short-tempered due to shifting deadlines, impossible deliverables, inadequate resources, or insurmountable constraints. Symptoms include snarky comments, mean emails, shouting matches, escalations, increased absenteeism, sleeplessness, and catatonic withdrawal. Treatment can include alcohol, complaining/venting to your peers, turning off electronic devices, long vacations, and no longer giving a damn.

"Angel, I don't know how to tell you this, but I believe you suffer from Irritable Project Syndrome. But you don't have to suffer alone. "

Irritable Project Syndrome by DanGarPrius October 21, 2016

IBS (irritable Biden syndrome) 

IBS or irritable Biden syndrome affects the carrier with a complete lack of bowel control. Folks literally can’t stop sh@tting themselves over the fact that Joe Biden is president.

“Let’s go Brandon”

“Dude, I think you’ve got IBS (Irritable Biden syndrome)

IBS (irritable Biden syndrome) by kacz December 25, 2021

Irritated

When your pissed at a school hoe and brandon

I’m so irritated

Irritated by Fuck everything April 24, 2018

Insistant Irritant

That one person that sees the absolute negative side of everything. S/he cannot commit to anything, due to the fact that everything can and will go wrong, and on the off chance that s/he does commit to something, s/he will make whatever it is absolute hell for anyone else involved. Despite this, always insists that "we" need to do more as a group or family.

Six stages of Insistant Irritant:
Insistence: "Why don't we ever do things together, as a family?"
Before commitment: "That will never go right."
Too late to cancel: "I thought that this trip would be a great idea, but now I think that it's going to be terrible."
During trip: "I'm having a terrible time."
After trip: "That was terrible."
Five minutes after previous quote: "Why don't we ever do things together, as a family?"

Insistant Irritant by Yggdrasilcutter December 26, 2008

Irritable Vowel Syndrome 

When you or your Scrabble opponent has so many vowels on their rack, they can't make a word on the board, or the only word that can be made is going to score very low. Complaining about having too many vowels and getting irritable reign over swapping a vowel tile and skipping a turn.

player #1: your turn.
player #2: dude, I can't even make a word, I have too many vowels.
player #1: swap some tiles, then.
player #2: no, it's ok. I will just make this two letter word and get a crappy point score.
player #1: sounds like you are suffering from Irritable Vowel Syndrome.

Irritable Vowel Syndrome by scrabble girl April 28, 2010