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Go Fuck Yourself with a cactus

Someone pisses you off, annoys you or is being a plain fucktard, Go Fuck yourself with a cactus
''I FUCKED YOUR MUM! ''Go fuck yourself with a cactus''

go fuck yourself 

Basically, means to just for the person to stop everything he/she is doing and find the nearest gun, point it under their chin and pull the trigger. That way they will no longer bother you and you can get some peace and quiet without their pure bullshit spewing from their mouths. If one continues you to harass you after you say this, you legally have the right to make them discover what your fist tastes like. They cannot sue you for any reason.
Latin origins of GO Fuck yourself:goeth fucketh yourselfus

go fuck yourself sideways 

to tell someone to hurt themselves, very badly; a curse.
When the ginormous corporation's troll fires you, you can say "go fuck yourself sideways".

why don't you go outside and play a game of hide-an-go fuck yourself? 

A deragotory question used to end a argument. Meaning to suggest that somebody leave the inside of a dwelling to go outside where he/she then hides in order to win in the game that nobody else will play in what the feel is a good hiding place and begins masturbating - by themself.
Hey, joe I really enjoyed this wonderful conversation on thermal dynamics, now why don't you go outside and play a game of hide-an-go fuck yourself.

Go fuck yourself 

Go have sex with yourself.
Guy 1: Hey bro wanna fuck?
Guy 2: Go fuck yourself
Guy 1: ok *takes dick and puts in asshole.*

Go Fuck Yourself Pie 

Fictitious pie to be served to an individual who needs to go fuck his/herself.
Bill: You really made an ass of yourself today during your presentation to the new clients, Frank.

Frank: Hey, Bill, I've got a nice piece of Go Fuck Yourself Pie here for you. Eat up, fucker.