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When you got diarrhea, or liquidy crap about to spew uncontrollably.
"I got a bad case of the shits!
The shits by Bob October 10, 2004

With the shits 

1: With it. Being trendy.
2: Staying strapped, or carrying a firearm.
3: On practice, on point.
4 something abnormal.
1: “Are you with the shits?” “Hell yeah. These new Jordan's got me fresh to death.”
2: “Aye. You with the shits?” “Yessir.”
3: *does something cool* “You really are with the shits today.”
4: (rando on twitter) You ever see something so off yo shit(s) you pass away for a minute? *link to a weird image*

get off the shits 

Yo you for real trippin like, get off the shits
get off the shits by uglyboyjason January 12, 2017
A phrase used to describe an uncontrollably runny liquid that squirts out of the ass.
Jake : Damn Kiersten you blonde hair is so soft Ahhh!
Kiersten : Oh Jake how would you like for me to wrap it around you cock tonight?
Jake : Oh that would be great but i'll have to pass I have The Shits!
Kiersten : Again you had The Shits last night what's wrong with you?
Steve : Hey Jake I heard you had The Shits do you mind if I sit in the bathroom with you I just love the smell of rotten poop?
Jake : Sure Steve knock yourself out!
Kiersten : I cannot believe this my man is going to give Steve A poop orgasam and I have to be alone tonight AGAIN!
Jake : Well you can always sit on my lap & ride my dick while I squirt!
Kiersten : Oh Go Fuck Yourself!
The Shits by SlopNChop February 13, 2018
Hawaiian way to say The Shit - notice the failure to differentiate plural from singular, (due to the heavy Pidgin speaking population on the islands)
Wow, I found $900.00 in the wallet I ripped-off from that tourist! That's the shits!
the shits by str8uph8 April 27, 2009

get the shits 

Australian, v, used in accordince with with someone to get angry, pissed off, snakey, dirty
When Ryan Adams or Pete Murray get rotation on triple J , I most definately...get the shits.
get the shits by herbie August 31, 2004