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A less formal way of saying Okay. It is given as a cheerful, bright... less intimidating response. It is also more used online rather than irl.
someone says "I'll be right back"
You reply with "okies"

Someone is doing something that doesn't bother you, you reply with "okies"...

someone is annoying you and your pissed off you say "Okay".. not "okies"
okies by anon March 5, 2004
Related Words

Opie Hughes

Once GREAT radio host, now unemployed loser, Opie Hughes has become a sad, lame, spiteful piece of shit who burns bridges and is hated in the radio and stand up comedy industries. Most past fans and colleagues wish him the AIDS.
Jesus Christ, joe, you’ve lost your job, your friends, and your wife fucked Bam Margera... you’re a regular Opie Hughes!
Opie Hughes by DJ FruityStoopid October 14, 2017
Over-Poweredness
The OPness of that character is extreme.
OPness by FP350z April 29, 2009

The Opie and Anthony Show 

"The Opie (real name Gregg) and Anthony Show" are consistent, quality morning commute-time-slot radio personalities. The duo (with "glorified intern", the hysterical Jimmy Norton present almost every day) are syndicated in the weekday mornings from 6-9, and then on uncensored satellite radio from 9-11(AM).

A typical show can include story bits (radio bits that evolve from a witty or shocking story by anyone in the studio), celebrity call ins, an appearance by one of many of the shows' "unique characters" (ex. a 50 some odd woman, who is homeless and a virgin) or all of the above. Not greatly structured (but by no means "amateur" or loose feeling), the show is non linear and follows little pattern, with Op generally keeping the pace unfolding with new topics, while Anthony (and Jimmy) keep it loose.

The show is heavily criticized by fans of Howard Stern ("Howie" as he is commonly known in studio) as well as Howard himself, because he feels the radio duo has taken a formula he created and perfected, and he is (or seems at least) greatly disrespected by it. The two radio shows have been feuding ever since.

For the skeptics, give the show a chance.
"The Opie and Anthony Show" is a constantly evolving, uproariously hilarious talk show that usually does not get the respect it deserves.

FRRUUUUUUUUNKISSSS!
Common nickname for red headed white males.
He's a redheaded, opie-looking fella
Opie by Opie Wan December 14, 2008

Opie and Anthony

the greatest radio show that ever existed (aka O&A)
q. who was wrongfully fired for a sex stunt gone horrably awry?
a. Opie and Anthony
Opie and Anthony by Suzi Watson November 9, 2003