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Downtown 

When a person thinks themselves so terrifically trendy that they are oblivious to the fact everyone around them thinks they are a douche bag. Often seen wearing Ed Hardy and sunglasses inside, and lacking any sense of modesty.
I went to the pub the other night but everyone there was wearing Ed Hardy and had a serious case of downtown. Needless to say, I left out of fear of STD's.
Downtown by T-Bone Lynch June 17, 2009

Downtown 

A player who is increasingly awesome and exceedingly skilled.
Downtown by TrigaHapy August 21, 2009

downtown 

A slang word for heroin, more specifically, "downtown brown". Can also be used as a verb for heroin use.
"Man, I'm gonna score me a bunnie of downtown."
"I'm goin' downtown tonight."
downtown by Johnny B. February 10, 2004

DOWNTOWN 

Opposite of "UPTOWN";a popular 1965 song performed by Petula Clark;
Man Buford,I surely am` bored. I think I`ll hop in the old jalopy and go DOWNTOWN and find me a woman!
DOWNTOWN by SIDNEY GOLDSMITH November 27, 2003

downtown 

When you throw any object into the low slung ho's tank top
downtown by Ian January 20, 2004

downtown 

shoving your cock far enough down a bitch's throat so that she gags and eventually vomits.
"Yeah man, I went all the way downtown on that slut, but now my cock smells like fucking bile."
downtown by daltonthegod May 6, 2005