To be completely plastered out of your mind. This word arose from Ireland, where people are usually assumed to be able to drink a lot. Their ability to drink so much came from their sadness over their small genitalia. But, when someone from Ireland lacked any alcohol tolerance, they would be outcast, in quite the same manor the Patriot fans are rejected by society at large. These people were considered nutmegged at the time of their drunkenness.
The ill-advised consumption of the common household spice Myristica fragrans, which, when taken in large quantities (about a tablespoon or more), will cause a minor inebriation characterized by light-headedness and intermittent mild euphoria alternating with the horrible side effects of intense nausea, severe headache, heart palpitations, abdominal pain, bone pain, muscle aches, and delirium; a cheap and unpleasant high commonly sought after by those without access to decent, safer drugs like marijuana, cocaine, opiates, and almost anything else besides Drano. May cause liver damage.
Friend #1: Man, I wish we had some pot. Mom's got nutmeg. You wanna do some nutmegging?
Friend #2: Fuck you, man ... the last time we did that I couldn't shit for three days and I felt like I wished I was only sick with a terrible case of the fucking FLU! I'll never forgive you for that SHIT!
Friend #1: SORRY! Instead of nutmegging, you wanna inhale some gasoline fumes?
Friend #2: Yeah, that'll suck ... but at least it's not fucking NUTMEGGING! I'll get the gas can and the paper bag.
Friend #1: Cool. You're a real friend. stupid Colorado medical emergency