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When you (instagram.com/m3rc.sy) lose a sports gamble during the Super Bowl 2024 to someone else (instagram.com/formulalyric)
"AW man I just got DUFFIED"
"I saw that instagram.com/parisfrancew just got DUFFIED by instagram.com/gwntt.Ign"
To get Your shit rocked by a closed fist.
Yo Son just got the shit duffed outta Him.
Duffed by Moe June 18, 2006
To get your ass kicked REALLY badly. If you got "duffed", you didn't just get punched in the face, hit the floor and kicked once or twice hard... you got hit in the face, hit the ground, then got hit in the face several more times, possibly had your head bashed into the cement, got kicked in the ears, neck, kidneys and various other soft spots on your body.
"Yung, that nigga D-Set laid up in the hospital. He smoked up that whole QP he was fronted by main man and got duffed."
Duffed by Krill Awareness April 15, 2006
Go hard, get retarded, dumb, any dude that steps up gets messed up
I go duffie.
Duffie by 23565 August 18, 2009

Duffed It 

Referring to when you royally screw something up. Sometimes when you miss an easy shot in a sport.
Oh he duffed it!
Duffed It by Doo Doo Delpra June 28, 2011
Duffie is a very loyal girl. If she falls in love with you, she'll never cheat on you. She's usually a bit of a tomboy, but very pretty.
She also has a good sense of humor and can be very sarcastic. Duffie is nearly perfect.
''I made Duffie my girlfriend.''

''Wow, good job! You'll be happy together!''
Duffie by grandpajoe November 18, 2013