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On The Run 

Commonly used to say someone is moving, but not in this case. In this case, it can mean, crazy, weird, or annoying.
Madison and Neal are on the run.

On the run baby 

A baby born to one or more crimminals; to have a parent who was convicted of a crime; a baby born to a mother who gave birth while imprisoned; a baby born to a fugitive of the law.
"on the run baby, conceived through a crimminal"
--Llyod Banks
On the run baby by B.O.S.S. Billa February 22, 2009

Yams on the run 

When your yam(s) accidently slip out of the pee hole or the side of your briefs and you don't notice it until it's too late.
I was changing in the locker-room last night and didn't realize I had yams on the run until I tried to zip my pants and...
Yams on the run by Minucci April 13, 2005

chicken on the run 

A girl who is only after money or something that you can give her, then she's gone. Basically a woman you can't wife because she's a gold-digger.
˜Yo aki, you know that girl Keisha??˜
˜Yea. She took all my money & I ain't seen her since.˜
˜Damn you got hit by a CHICKEN ON THE RUN˜

Lemmings on the Run 

A song by E-rotic, often considered the best ever created.
Right before I ejaculate I always think "We roll like lemmings on the run"
Lemmings on the Run by E-rotic January 22, 2006

Take it on the run

Made popular by the song of the same name as most popularized by the band called REO Speedwagon in the 1980's era, take on the run means to run away, usually from a bad or uncomfortable situation.

It may also now refer to taking a food order to go, aka running with it.
He suspects that you're cheating, so like a coward instead of confronting the situation you leave town and take it on the run.

I don't have time to sit down and eat. I'll just take it on the run.