1. To tell someone new or uninformed how to survive in their environment who to respect who to get over on and over all how to win. (typically relating to the drug game or pimp game.)
2. to tell you how it is and how it will be.
"let me put you up on game homie before you get your head took off by these cats." Typically used as westcoast terminology.
The Game used this phrase as a hook for one of his songs.
(v) When a friend or another male interferes with your interaction with an girl. Usually by bringing the attention to himself by boasting or other means. Frequently occurs when the other male is jealous of your progress; an extremely douchey form of cockblock
John: So I finished that book you were telling me about