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Difference between his asshole and a hole in the ground. 

A metaphor relating to a stupid, ignorance, and educated person that can not distinguish similarities between items or objects.
George is so stupid, he don't know the difference between his asshole and a hole in the ground.

Like Satan Crawled Up His Asshole

To describe an instance of one being so unbelievably angry, that such anger is unholy.
"Sometimes, when Josh rages, he gets so unequivocally, royally pissed off, that it's like Satan crawled up his asshole. It's actually quite frightening."

Tripped over his own asshole 

Someone that is super ignorant, super hateful and super motivated by cruelty. The have become such a large asshole that they can actually trip over it.
When he said, " We birthed a nation from nothing. I mean, there was nothing here. I mean, yes we have Native Americans but candidly there isn't much Native American culture in American Culture," he literally tripped over his own asshole.

Mickey mouse fucks Minnie mouse in the asshole and loses his boner as he enters her urinary tract and gets stuck and has to pull out but his dick falls off and now he's gay 

Did you see that one porno called Mickey mouse fucks Minnie mouse in the asshole and loses his boner as he enters her urinary tract and gets stuck and has to pull out but his dick falls off and now he's gay?

No Kyle, what the fuck man!?

His Assholiness 

Melania’s initially secret pet name for the 45th POTUS which was eventually adopted by many in 45’s administration who worked closely with him.
Let’s get His Assholiness in here for the photo op and then he can be released back to his room while we discuss this issue further.