1. To not care at all about something; to have no opinion whatsoever about it. Often used dismissively in the negative to tell someone that what they are talking about has no relevance whatsoever to the listener.
2. A humorous way of saying you are constipated, and therefore "can't give a crap."
Boss: Dilbert, that is the dumbest idea you have come up with yet. I reject your proposal.
Dilbert: You never like any of my ideas. One of these days you're going to push me too far, and I'm going to quit.
Boss: Frankly, Dilbert, I do not give a crap.
Doctor: So, Bill, I understand you're constipated?
Bill: Yep, doc, I can't seem to pass those poops because they're just too big. I don't give a crap.
dick guitar, jamming out on your peepee. dick guitar is when your most likely pissed on some of that firebreath that your like "eey fuck it, im gonna play guitar on my wang hole" 'day later your sore because you needed it to sleep.
Dick guitar: man im at my peak i might as well job it off for the night,.. time to jam down a solo for bed.