It is a multi-purpose word used in an awkward situation, to disagree, to say gross, to signify a time to laugh, or just to shout out whenever you need it!
OMG, that chick is so woof!

or

(awkward silence) Woof mcgoof
by Fogg Dogg November 21, 2011
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Coined by Dr.Perry Cox from the medical comedy show Scrubs, it is now used as an overall exclamatory remark towards anything deemed angering, sexy, cool etc.
(pretty woman kisses her male friend without warning; causes a long winded "oooooooh" from the audience)

Viewer: woof...
by Guido Sarducci April 2, 2008
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An external expression of the internal truth that it's getting good in here.
(Purely hypothetical) Dude #1: "I can't believe it, the Blues just won the Stanley Cup!"
Dude #2: "Woof!!"
by dmbcpa777 August 10, 2012
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A term used that can mean the same as “damn” or “holy cow” or “wow”
Let’s say you see a hot girl. Instead of saying “damn she’s cute”, just look at your bud and go “woof” and maybe do an eyebrow raise or wink.

Or “wow that’s a big...”

instead just say “woof” with an eyebrow raise or a wink.
by Urstumbler August 6, 2018
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adj. To express utter dissapointment. To signify extreme dislike.
Wow, I have an exam today and forgot to study...woof.
by Paul Kazanjian October 31, 2005
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a scary looking guy. referred to as a "woof woof".

woah! dude! look at that woof woof!
by milkyway December 6, 2006
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A verbal insult that implies how one is so unaesthetically appealing to the the eye that even the canine species would find him/her unrecognizable to a point where it would feel compelled to bark as a warning for said individual to maintain their distance.
"Man my woof factor is through the roof today. I haven't showered in over a week and I no longer fit in my sweat pants"
by Supercalafragatastic April 28, 2013
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