area of expertise, a particular skill;

A term used to reference cannabis/marijuana/weed.

In baseball this is the part of an individual's swinging range in which as a hitter they can make the best contact with the ball. If a pitch is right in your wheelhouse it is right where you want it, in the spot where you have the best chance of hitting it well.

The term is also often used to explain something that falls into a person's area of expertise.

Anything that can be acted on with confident success.
I'm guessing it originates from the fact that a wheelhouse is the room on the bridge of a ship where you steer from, providing you with clear view & control to steer the situation.

Wheelhouse- Another southern, very American word with meaning stemming back to into its origin in the mills. A wheelhouse in a mill is where water power (streaming water) is used to generate mechanical power by turning a huge wheel. The wheelhouse is where the mill sources its power, this translates to the commonly accepted definition today, the wheelhouse is where power is sourced from. In terms of throwing a punch (a strike) or swinging a baseball bat, In one's wheelhouse is where these strikes are most powerful.

An area of knowledge, specific interest, and familiarity...

To consume quickly and gluttonously, especially as in junky snack food meant to be shared.