Often used as sarcasm in response to someone who did something you didn't want doing.
Jack just cock blocked John

John: thanks a lot, Jack
by Ophooo September 16, 2013
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Being super sarcastic and not thanking you for anything at all.
“Thanks a lot, Sam,” Matthew said.
by dr.c__12 July 17, 2018
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A standard response to an awkward/inadvertently offensive/incredibly personal question.
“Listen I have a weird question and it’s not like it’s an issue but, I can’t find your balls dude. Do you have balls?”
“Now I have to worry about the size of my balls? Thanks a lot, Liz.”
by AprilUnderwater December 27, 2019
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