When you ask a friend if he is in or out, he gives you a long and unnecessary reason why he's out.
Dude 1: You coming with us man??
Dude 2: I have to see my PO then run to the store and I have some projects to work on around the house...
Dude 1: Quit shark tanking me, are you IN OR OUT??!!
Dude 2: ...and for that reason, I'm out.
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.