Singular Sclerosis 

The retarded cousin of Multiple Sclerosis, this disease only affects male genitals, causing complete numbness, leading to permanent, untreatable erectile dysfunction.

Doctor: You've been diagnosed with Singular Sclerosis. You will never be able to pound Zucker's fat, hairy ass again.

Stelter: God dammit Donald Trump!

Singular Sclerosis by sciflyer.25 April 22, 2020

indigo sclerosis 

Indigo Sclerosis, or IS, is a short term disease that cant affect your brain, spinal cord, and the optic nerves in your eyes. It is a very rare variation of singular sclerosis. This condition is completely asymptomatic and it is particularly difficult to diagnose. Only by close inspection of the sclerosis will one find a sleight discoloration.

Sammy: Did you hear Matt was diagnosed with Indigo Sclerosis?

Mark: Yeah, he told me he was tired of explaining it to people over and over and that he wished there was more information about it available on the internet.

indigo sclerosis by Dixon_Ticonderoga January 5, 2017

Multiple Sclerosis 

Multiple Sclerosis
A disease that no can can see that you have while you go blind, lose your ability to walk and talk normally and eventually die seven years before you ordinarily would have.
Your immune system thinks your nerve coverings are an all you can eat buffet.

Man:You shouldn't be out in public when you're drunk.
Woman:I'm not drunk. I have multiple sclerosis.

Multiple Sclerosis by Karinmag June 25, 2016

Lichen Sclerosis 

LS- is short for Lichen sclerosus (aka lichen sclerosis or lichen sclerosis et atrophicus) is a painful skin condition that typically affects the vulva (or penis) and anus. In women, LS falls under the general category of vulvodynia (chronic vulvar pain). It is not a contagious condition.

"Oh yeah, she has got LS"
"She's got what?"
"Lichen Sclerosis"

Lichen Sclerosis by Tom725 October 9, 2007

amyotrophic lateral sclerosis 

A progressive, terminal disease where one's motor neurons degrade. This causes muscle weakness and atrophy and eventually death. Also known as Lou Gehrig's Disease.

"He died of amyotrophic lateral sclerosis."

amyotrophic lateral sclerosis by Samantha Wilson May 12, 2007

amyotrophic lateral sclerosis 

A huge ass name for ALS.

He has amyotrophic lateral sclerosis - Dan
The fuck is that? - John
ALS - Dan
Oh -John

amyotrophic lateral sclerosis by x crackersmacker x March 1, 2010

Thotticus Sclerosis 

A disease those known as fuckbois contract once they overload themselves with a surplus amount of thotties.

Symptoms Include:

Clamidya, Gonorrhea, ED, Autistic Screeching, Nutt Deficiency, PTSD, Arthtritis, Anemia, Penile Reduction and Retardation.

Often one who contracts Thotticus Sclerosis will wind up as societal failures, and become one with 4chan.

Person one: "Hey man, have you heard of Ronnie, I hear he's contracted Thotticus Sclerosis and now is in 4chan quarantine."

Person 2: "I warned him man, he broke the bro-code..."

Thotticus Sclerosis by FlowGunner May 23, 2018