Singular Sclerosis

The retarded cousin of Multiple Sclerosis, this disease only affects male genitals, causing complete numbness, leading to permanent, untreatable erectile dysfunction.
Doctor: You've been diagnosed with Singular Sclerosis. You will never be able to pound Zucker's fat, hairy ass again.

Stelter: God dammit Donald Trump!
by sciflyer.25 April 22, 2020
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indigo sclerosis

Indigo Sclerosis, or IS, is a short term disease that cant affect your brain, spinal cord, and the optic nerves in your eyes. It is a very rare variation of singular sclerosis. This condition is completely asymptomatic and it is particularly difficult to diagnose. Only by close inspection of the sclerosis will one find a sleight discoloration.
Sammy: Did you hear Matt was diagnosed with Indigo Sclerosis?

Mark: Yeah, he told me he was tired of explaining it to people over and over and that he wished there was more information about it available on the internet.
by Dixon_Ticonderoga January 05, 2017
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Multiple Sclerosis

Multiple Sclerosis
A disease that no can can see that you have while you go blind, lose your ability to walk and talk normally and eventually die seven years before you ordinarily would have.
Your immune system thinks your nerve coverings are an all you can eat buffet.
Man:You shouldn't be out in public when you're drunk.
Woman:I'm not drunk. I have multiple sclerosis.
by Karinmag June 25, 2016
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Lichen Sclerosis

LS- is short for Lichen sclerosus (aka lichen sclerosis or lichen sclerosis et atrophicus) is a painful skin condition that typically affects the vulva (or penis) and anus. In women, LS falls under the general category of vulvodynia (chronic vulvar pain). It is not a contagious condition.
"Oh yeah, she has got LS"
"She's got what?"
"Lichen Sclerosis"
by Tom725 October 09, 2007
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A progressive, terminal disease where one's motor neurons degrade. This causes muscle weakness and atrophy and eventually death. Also known as Lou Gehrig's Disease.
"He died of amyotrophic lateral sclerosis."
by Samantha Wilson May 12, 2007
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He has amyotrophic lateral sclerosis - Dan
The fuck is that? - John
ALS - Dan
Oh -John
by x crackersmacker x March 01, 2010
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Systemic Sclerosis

Autoimmune, inflammatory condition causing body tissues to essentially thicken. Also known as Diffuse Scleroderma. There is commonly skin involvement, but in subtypes like Sine Scleroderma only internal manifestations are seen.

(Not to be confused with its less severe counterpart, Limited Cutaneous Systemic Sclerosis aka CREST Syndrome)
"The imaging for Sideroom 3 is back, seems his LCSS is flaring up."
"Wait, wasn't Systemic Sclerosis our main differential?"
"Yes but there was no indication of internal organ involvement on the scans."
by Computerised Rectal Exam January 18, 2024
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