Short for Amyotrophic Lateral Sclerosis, otherwise known as "Lou Gehrig's Disease". It's a neurodegenerative disease characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, and difficulty speaking, swallowing, and breathing. ALS is the most common of the five motor neuron disease.
Peter Frates was diagnosed with ALS, and due to appearences at various meetings and such events, the ALSIceWater challenge was created.
by A-person_yay August 18, 2014
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1. Acronym for All Ladies Shaved.
2. Porn industry niche code for a video in which all of the girls pubic hair has been shaved.
Excuse me porn store clerk, could you please tell me where the ALS section is?
by eq5150 January 6, 2009
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Mr. D.: Griff, you are on my ALS list again"
Griff: yeah and now my grade is at a*t.."
by J Do March 29, 2008
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An acronym for "After Lunch Syndrome", commonly occuring in teenage girls after digesting their midday meal. During ALS the female specimen exeriencing this will become mindless, berserk, delirious, and fruity. This peculiar syndrome only occurs within females because of the breast hormones raging inside of the said female's chest, yearning to be sated by male interaction. This condition has yet to occur within the male gender, but studies have shown that an obese homosexual male with above average sized breasts, or man boobs, may develop these breast hormones over time and become subject to ALS. On rare occasions the female specimen may also become extremely horny, lunging for any male within her radar. If this should occur, it is strongly advised that all males should be removed from the vicinity, otherwise there is a high chance the female will attempt to straddle any male she may get near.
Emily: Rawr! I want sex! Come over here Sung! Time to make me a portuguese breakfast!

Andrew: Woah woah Emily, you alright?

Andrew(to Jesse): I think she's experiencing ALS.

Jesse(to Andrew): Yeah, we better skidadle on outa here.
by BrB Bowflexin Son July 8, 2009
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A bad disease, I don't know anything more about it, and lets be honest, neither do you or anyone else that has done the ALS ice bucket challenge.
Girl 1: I just like totally did the ALS ice bucket challenge to raise money and awareness for ALS woooooooo!!!!
Girl 2: What does ALS even stand for?
Girl 1: I have no idea.
by binbucket August 31, 2014
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After Lunch Syndrome.

The feeling you get just after lunch when you cant concentrate and want to have a nap.
"I think ALS has just kicked in. I can hardly keep my eyes open!"
by Claire240 June 6, 2007
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Having 'After-Lunch Sex' or ALS means sex with full stomach which is very unhealthy, first because of the intense ‘physical activity’, and then for gulping energy drinks and powerbars to make up for bodily ‘resource loss’ afterwards.
Is in contrast with other healthy types of sex i.e. BLS (Before-Lunch Sex), LNS (Late Night Sex) and EBS (Early-Bird Sex).
Jude: A friend of mine has challenged me to ALS on Facebook. That’s not proper. I’m married now!
Larry: He doesn’t mean after-sex lunch, you idiot!

Had an extra large pizza the other day followed by ALS with the hot girl from work. Threw up before I could finish my Snickers!
by Silent Lake August 29, 2014
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