Because Cain was the first murderer in the Bible, having killed his brother Abel, people use the expression "raising Cain" to describe acts of violence, criminal activity, or any other mischievous acts.
Robert: Whatcha gonna do tonight?
Michael: Nothin' much. Guess I'll just be out raising Cain.
by Tina R. Collins November 10, 2005
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raising Cain:

1. The act of raising or striking with a cane in anger.

2. Raising Cain from the grave, as in biblical times. (Cain and Abel brothers.)
1. Johnny was raising Cain.

Johnny was so hurt he began raising Cain. (Woke the dead.)
by Carolyn N. Holtzman July 09, 2006
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A tactic by the television comedian Steven Colbert to demonstrate the stupidity of the 2012 Republican presidential primary process by encouraging democratic and independent voters (as well as Colbert-supporting Republicans) to vote for resigned candidate Herman Cain in the South Carolina open primary vote rather than any candidate then pursuing the Republican Party nomination.
As Stephen Colbert said, "If you like me, you're gonna love voting for Herman Cain." The word of the day: "Raise Cain!"
by Dub Deez January 17, 2012
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