Any drug that can be smoked.
Cop 1: Did you find anything in your vehicle search?
Cop 2: Yeah, found a couple rap crap cd's and a small bag of puff stuff.
by boo&brasen January 27, 2013
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It is a sex act:

While having sex doggy style you hand your partner a joint, they take a hit and when they start coughing you stick your dick in their ass. The object is to cum before they stop coughing!!!!!!
Last night my girl and I were getting after it, I gave he some of my fresh greens, she took a hit and I puff and stuffed that bitch!
by imakenewsides March 4, 2010
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To smoke while shoving your schlong into any orifice.
" C'mon man...are we leaving?"
"Yeah, i'm just finnishing up on a puff n stuff".
by mavros April 12, 2006
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The art of tucking your testicles between your legs and stuffing your own scrotum into your rectum. The final act is farting out the scrotum.
Josh: What are you up to tonight, Bobby?
Bobby: I think I’m gonna go home, drink a few beers and do a little Stuff & Puff.

Josh: What is that?
Bobby: I’m gonna stuff my nuts into my ass and fart them out!
by Catwrencher October 5, 2018
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The sexual act of smoking a cigar during intercourse and cramming the non lit end of a cigar into her vagina or anus.
Dude, I just gave Angelique the peacock puff-n-stuff. She smoked half the damn cigar too!
by Mr. Clinton January 3, 2014
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