Physco Bitch Share definition Flag Somebody who will go completely crazy on somebody for simply no reason, many times. Also a nick-name for a person who acts that way. Larissa calm down, stop hitting me, and yelling at me, your in Physco Bitch mode again. Physco Bitch by NckZ August 13, 2011 0 0 Get merch Get the Physco Bitch mug. Buy Now — $32.95 See more merch