It's often used as a response to something vaguely repulsive or strange.

It's can also be used as an exclamation for "that was a weird sentence you just put into the world"
Some strange being: "hey, you want to look at a compilation of sonic mpreg with me"

Slightly sane individual: "none of those words are in the Bible"
by Toastwithjam March 16, 2022
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