main boo Share definition Flag your main girl, not in a serious relationship but basically she gets the dick first but they can see other people and shit. DeAndre: manne my main boo is out i need muh gutta bitch Carlos: i feel ya bro main boo by 123fukme January 17, 2008 0 0 Get merch Get the main boo mug. Buy Now — $32.95 See more merch