a pr0n website. A right-handed user would hold the mouse in his/her left hand and stroke it with the right.
Ever since I lost my job job, I've been designing left-handed websites. Eventually, I hope to make a contribution in a less ... uhh... behind the scenes way.
A pornography site on the internet. The name is derived from the practice of using the left hand to manipulate the mouse, thus leaving the right hand free for self-abusing purposes
"Nah, I think I'll just stay home tonight, have a few drinks, and find a left-handed web site or two"