fuffnuts Share definition Flag general expletive meaning something similar to 'damn' 'darn' 'shoot' 'balls' 'blast' or 'shit'. often used in the midlands. 'oh fuffnuts' fuffnuts by naughtyfox August 30, 2011 0 0 Get merch Get the fuffnuts mug. Buy Now — $32.95 See more merch