disquietude Share definition Flag Having the position that the current situation is untenable. The creation of a non quiet state. The disruption of one's "groove". Dude, with all that Gregorian Chanting, you've filled my world with disquietude! disquietude by AceTW September 26, 2004 0 0 Get merch Get the disquietude mug. Buy Now — $32.95 See more merch