Something that is said to a dude who has said or done something so inexplicably stupid that his gametes need to be immediately removed from the gene pool.
Ryan: Yeah, I thought it best to get back together with her again.
Josh: Isn't this the fourth time?
Ryan: Well, yeah.
Josh: Fucking castrate yourself.
When children have too much candy causing them to act crazy or do crazy things.Also known as over-canderation meaning the process of becoming over-canderated or a candy high.
"When Kyle got back from trick-or- treat he was bouncing off the walls. I could tell he was deffinately over-canderated"