A horrible smell that comes from a wall locker as a result of sweat-soaked clothes piled upon each other over a long period of time. Usually occurs with college students stockpiling their dirty laundry.
Holy shit Travis, this room smells like foot and ass disease!! When was the last time you washed your nasty ass clothes?
by UMC February 1, 2008
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To be defeated or beaten on many levels in many facets of life including but not limited to sports, school, and fisticuffs.
The inability to succeed at anything despite enormous effort.
Jane: Last week Bobby spent 24/7 studying for his Biology final and he still failed.
Alex: I know. Even the kid with a 65 IQ topped his score. He has a major case of Foot-In-Ass Disease.
by OneLostChapter February 15, 2008
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Head Up Ass Disease, in other words, someone has HUAD when his/her perception of a situation is so unusual or extremely inaccurate, most are left speechless.
by ReallyGood January 2, 2012
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the combination of extreme exposure to heat, humidity, and sweat, that causes chafing around the buttock region. Can normally be supressed by applying medicated powder to the infected region, though relapses may occur due to fact that this disease has no cure.
Jimmy had a major case of Raw Ass Disease (R.A.D.) after his girlfriend kicked him out of her ride and made him walk 5 miles in the Georgia heat.
by Jake Thompson August 15, 2007
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someone being a major bitch constantly so people think they always have a stick up their ass
I think my boos has a case of stick up ass disease
by bretttttttttttttttttttt July 31, 2006
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Essentially the inability to control one's bowels from both openings (mouth and anus) simultaneously. Usually brought about by the ingestion of improperly prepared food containing harmful bacteria or allergens.
Dave: Did you hear what happened to Steiny out in India?

Josh: Yeah, he shat and barfed all over his bed after he caught ass-and-mouth disease from that street vendor!
by PME InfoSource April 25, 2007
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