A being of such a massive intellect and high IQ that they are completely unable to function in plebian society.
Oliver is such a god at Smash Bros, I wonder if he has up syndrome.
by Banana Hammie October 29, 2019
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When you're so smart your brain is disfunctional.
Wow that guy has severe up syndrome!
by big boi dan December 11, 2018
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Up-Syndrome is when you have more than 62 chromosomes (basically being a SPED Class in one person), this usually occurs in when a male and a female have reproductive sex over the age of 50.
This kid with Up-Syndrome is CRAZY!!!
by The Up-Syndrome bot April 12, 2019
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Up Syndrome: You got down syndrome so bad, you probably got up, left, and right syndrome too
by Dickweed69 August 23, 2010
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"I'm so smart I have Up Symdrome."
by tug July 10, 2003
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having the disorder that makes you tie one octillion balloons to your house daily
up syndrome isnt the opposite of down syndrome
by brian33337 October 14, 2023
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The condition where genitalia is in a perpetually happy state.
"Tom came down with a case of up-syndrome soon after meeting Caroline."

"We always thought Susie was a bit weird, but we didnt know for certain until her secret reared its ugly little head -- she was diagnosed with up-syndrome."

5:00 News Report:
"Rare condition found in man with up-syndrome... Are two penises better than one?"
by PetShelterPimp March 6, 2005
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