The word used to replace 'share' in a request to do so with someone.
Sam: ' I just brought a pack of gum'
Matt: ' Nice, wanna go twosies on it yeah? cool.'
by MDWatson June 29, 2008
To crap. Also, a Deuce. Number Two.
The Todd: "I've got a Doozie of a Twosie!" - Scrubs
by D-Biz October 14, 2006
N. defecation. Derived from the term number two. Originally used in the sitcom Scrubs.
"I gotta go making twosies."
by Scrubby May 6, 2008
spar's strong white cider,

sold in bottles of 2 litres, originally for 2 pounds, hence the nickname twosies, often abbreviated in writing to "zz".
"hey benn, you drinking twosies tonight?"
by camelia S October 11, 2007
v. to need to poop, usually soon.
"Geez Hilty I got a twosie in the bank!"
by Delta Sig December 10, 2007
When you pull an all-nighter of Halo two online and forget to brush your teeth, resulting in bad horrible breath.

Can also be used with halo 3 if you have an X-box 360
Stan and Justin were up all night playing halo two online.

How do you know that?

They have Halo twosis
by Steve Ph October 22, 2008