Meaning STD (a four) or someone having an STD, mainly females living in the US age group 15 to 19. This word came the statistic on CNN stating "1 out of 4 girls in United States American ages 15 to 19 do now have an STD, aware or not"
Dude 1 "Hey man you heard about the new girl, pretty hot?"
Dude 2 "Yeah I've seen that fine girl!"
Dude 1 "Well are you goin'a tap that or what?"
Dude 2 "Man if she ain't a virgin she a 4 in my book."
Girl "No, I've had sex before."
Dude 1&2 "Four!"
by Brian AB April 7, 2008
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Four cups, four balls, four players, two teams. It would be four teams, but that would require a very large table.

Throw the balls in the cups and drink, its really not that hard.
Pardon me good sir, but would you like to play some fours?
by gonzonokappasig February 19, 2017
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A reference to "four out of ten" as a 'rating' for girls. Used especially to signify a lack of talent in the vicinity.
"What are the girls like at Cambridge"
"Not so good. There's a lot of four going round."
by Nick 3000 May 24, 2005
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a combination of "fat" and "whore", used to insult a person who is a fat whore.
She is overweight and promiscuous, what a four.
by Sara W. July 31, 2006
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The ultimate alcoholic challenge where you have to drink four four loko in four hours
Chad: "Yo, bro, are you ready to take on the Four Hour Four Four Loko Challenge?"
Brad: "Yeah man! I can't to go to the ER!"
by Eric02 April 18, 2019
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