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It is originated from chinglish "zhe bu ke xue". It is always used to express surprise or astonishment at unexpected or unusual things. By saying that, one means the thing he/she is told or sees is out of his/her expectation.
A: You know what, Tom just got the offer from Morgan Stanley, but he rejected it and decided to go to a small local bank.

B: Oh, that is not science.
by ritotila April 26, 2014
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