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TFU, an abbreviation which stands for "The Fuckest Uppest", is generally used to describe something which is dangerous due to a capacity for violent unpredictability. It suggests something which is "the most fucked-up" in the sense of being the most unstable, irrational, erratic, easily provoked or insane with anger, and therefore something not to be messed with.

The term first came into popular usage in the BBC comedy programme 'Spaced' (Simon Pegg's character paints the letters on his battle robot in order to make it more intimidating). Apparently TFU is the graffiti signature of one of the members of the Spaced crew.
ED-409 from Robocop is TFU. Compared to him the Terminator is like a special needs child with a silly haircut.
by Megastar July 08, 2006
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Oct 3 Word of the Day
I couldn’t care less (but one must keep up appearances, right?)
Frenemy has a family tragedy. "Thoughts and prayers."
by November 05, 2018
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The Final Upset- A band based out of Orange County CA formed in 2012
TFU is The Final Upset.
by TFU,T.F.U,T.Fu,tfu,Tfi,tfy January 16, 2013
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T.F.U. Too fucked up... When you go out and get too wasted and do some fucked up shit or black out and not remember any of it.. You text it to your friends After a crazy night because you did some crazy shit.
What happened to you last night?
I passed out in the Steak n Shake drive thru and a cop had to take me home. I was too tfu.

When going to SIUC for the weekend you know you are going to get too fucked up

Text:TFU last night FMP(Fuck my pussy)
Dude, I know I was TFU too
by maynard87 September 08, 2012
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"True Freaks Union"
From South Park episode 601- Freak Strike in which Butters puts balls on his chin to get on TV and win a prize for Stan Kyle and Cartman
Stan: This is gonna be so funny!
Butters: Uh, it sure is!
Kyle: But how are we gonna get the balls put on Butters' chin?
Butters: Hah yeah, how are we go-? Wait... Butters' chin?
Kyle: Yeah.
Butters: Uh, but that's me. I'm Butters.
Stan: We know. You're the one doing it, Butters. Who'd you think we were talkin' about?
by Lornapie June 08, 2005
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