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In Asian dramas this is Seconf Lead Syndrome. There are the two main leads that are destined to be together but you always have some poor, handsome secondlead whofalls for the main lead. While they may be winning with the main lead for a while, they almost always lose in the end. SLS applies to the either female or male second lead, but usually more sympathy is felt for a male secondlead. A lot of female second leads come off bitchy and cunning.
Friend: *crying* '"noooo, this can't be"
Friend#2: "What"
Friend: "My ship is destined to sink and never become cannon, why did I fall for the second lead"
Friend#2: "I think you have come down with a classic case of SLS"
Friend: "Not second lead syndome, nooooooo"
by Princess Pandamonium February 11, 2016
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Apr 15 Word of the Day
to take an unfortunate loss and turn of events.
"last night took an L, but tonight I bounce back" - Big Sean (2017)
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by urbansammy January 20, 2017
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Abreviation for the swinger/alternative sex/lifestyle website SwingLifeStyle.
I saw your mother on SLS last night, guess that explains why you don't look like your father.
by Katty kat October 29, 2007
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A fisherman's term meaning "sore lip syndrome". This commonly occurs 1. When a fish is caught and thrown back. 2. When fish is hooked but gets off the hook. 3. When nothing bites in a specific area because a big shot fisherman was there recently and hooked all of them. SLS can last for a good while. Unless the fish are dumb, and you're just lucky.
Example 1. Yeah nobody will catch him again for a while. That fish has SLS.
Example 2. Aw man he was a big one too. He won't bite again because of his SLS.
Example 3. Man the fish really aren't biting today. They may just have SLS from yesterday's fishing tournament.
by IAMGONDOR April 02, 2011
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Stands for 'Slit Lip Syndrome'; very common trait involving someone with a lip size equivalent to a slit or a sheet of paper; Most noticeable when lips are closed or when a person expresses a dominant grin
"Did you kiss him?"
"I did, but because he has SLS I got a lot of teeth and gums."

George Clooney and Amy Schumer are just a few celebrities who have 'SLS'.
by momopeachgurl November 21, 2016
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