Pac Disease Share definition Flag A deadly fast spreading disase in which rappers act like and pretend to be 2Pac and fail to be origninal Tha Realest, Ja Rule, Blac Haze, Master P (and the entire No Limit label) Pac Disease by NanyoBizzness October 8, 2003 0 0 Get merch Get the Pac Disease mug. Buy Now — $32.95 See more merch