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It means uncle, although in anime character regularly use it in its less formal form where it functions more as "mister" or "sir." It's just an informal, but not necessarily rude, way to refer to an older man than yourself that you're unfamiliar with.

That's all I wanted to get clear. Most definitions stop at uncle and barely explain the secondary, and probably more common, use for it. "Ojisan" always means "sir/mister" unless they're actually they're uncle.
"You dropped your wallet, Ojisan" = "You dropped your wallet, mister/sir."
Ojisan by i8toast7 November 16, 2018
Related Words
Ojesa Ojisan Onesan Odesa oesaid Ojeanne Ojesh okesanya oresama Obesabri

Mater tua tam obesa est ut cum Romae est, urbs habet octo colles

A 'yo mama' joke in Latin that means Yo mama is so fat, when she is in town, Rome has 8 hills. This is funny because there are 7 hills in Rome.
Roman1: Mater tua lupa est (Your mother is a whore)
Roman2: Mater tua tam obesa est ut cum Romae est, urbs habet octo colles
Roman crowd: Ooooh!
Very Handsome And Strong Family
There are no gays in the family and only straights. Most of the Ojeda’s have six packs

So be careful around them. They are true and loyal to friends and can run at high speeds
They are Proud Mexicans. They are nice and out going and love to play sports
P1: who is that?
P2: that’s an Ojeda

P1: damm they are very big and sexy
P2: I know they get all the bitches
P1: damm I guess all the Ojeda’s get the bitches
The last name of multiple famous people. Most are from South America. These people are very talented, and smart.
Also the name of a high-class hotel.
Octavio Augie Ojeda, Eddie Ojeda, Martha Ojeda, Marino Ojeda, Santiago Ojeda...
Ojeda by paramoretwilight March 30, 2009
"Oresama" is both an overly-self-confident and narcissistic way of saying "me" in Japanese.
Miyavi said when asked, Special Talent: oresama
oresama by Symshia February 24, 2007
Japanese for Uncle. Not to be confused with Ojiisan, which means Grandpa.
My Ojisan is going bald.
My Ojiisan is going short.
Ojisan by Spazmatik Illusion January 18, 2006