Nyquilepsy Share definition Flag The sudden onset of sleepiness which occurs shortly after taking a dose of NyQuil. I took some cold medicine last night and I don't remember falling asleep; I must've had Nyquilepsy. Nyquilepsy by Cloclia December 20, 2013 0 0 Get merch Get the Nyquilepsy mug. Buy Now — $32.95 See more merch