Mista-isam Share definition Flag Mista-isam; A string of words that a person says that make no friggin sense, but sounds funny. Is usually an insult. "That friggin tiddy goblin took my toast!" Mista-isam Mista-isam by Amaya Ayaka November 7, 2021 0 0 Get merch Get the Mista-isam mug. Buy Now — $32.95 See more merch