When you see someone's picture in a meme and it looks like someone you know.
Rachel: Have you seen this meme? If you squint it looks like John.
Amy: I don't have to squint before you said that I thought it was John.
Rachel: Do you think it could be him? He's been memified!
It is said of the situation where a person has the bad luck to make contact with his testicles against an undefined surface or object, intentioned or not.
Given the nature of the word, it is more appropriate to design cases where the interaction is made with a moving object, for example, a ball.
Although it is extremely painful for the victim, it tends to be considerably funny to people who witness it.
Today in the baseball game the pitcher took a nutshot; the baseball hit him in the nuts.
Man, I just watched the funniest nutshot video ever.