noun: a bout of diarrhea that comes on so quickly and ferociously that one would stop at any location with a working toilet- even a Mean Gene restaurant in the middle of West Virginia.
also used to describe any horrible fecal experience
I hope that aint a mean gene comin' on because we are miles from toilet paper.
DANG, did you see that? He just put the Mean Gene upside his head!
You don’t tug on Super Man’s Cape, you don’t spit into the wind, you don’t pull the mask off of the Lone Ranger and you don’t mess around with Mean Gene!