2
Get really angry and lose your self-control. Derogatory, as implies that it wasn't a reasonable reaction in the circumstances.
After Dad saw my picture on the front of the porno DVD, he completely lost the plot.
by Observer52 August 23, 2005
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3
To lose the ability to cope with or understand what's going on around you.
Feminist Frequency is complaining about lack of diversity in female character designs in OverWatcth, a game that went out of its way to have the most diversity in female character designs. Way to lose the plot, Feminist Frequency!
by JohnSmith1495 September 03, 2016
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4
To lose all self control and go absolutely bonkers. Make stupid and irrational decisions. In most cases only lasts a few minutes but sometimes can be permanent which will require long periods of habitation in psychiatric hospitals with the men in white coats.
Jimmy will lose the plot when he finds out someone stole his New Kids On The Block album.
by Whowantspeas November 07, 2018
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